Dominguez is a former member of ABS CBN's elite circle of homegrown talents, Star Magic. But later in 2010 she did not renew her contract to do project on ABS-CBN's rival station GMA Network. She supposed to be a lancher actress but later she decide to sign an exclusive contract with GMA Network dealing to be a regular host and performer of I Laugh Sabado currently airing on GMA's subsidiary station Q, she is also part of the situational comedy show Pepito Manaloto. And be the cast of Endless Love series in GMA.
Janna's biological mother left her and is now living in Japan. Her father married a 25-year-old woman who became her stepmother. Her father continues to work in a construction in Japan.
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